Currently, there are a few provisionally licensed vaccines against COVID-19, 146 candidate vaccines in clinical development, and another 195 candidate vaccines in preclinical development. Afterward, global efforts focus on developing safe and efficacious vaccines for its prevention. The coronavirus disease 2019 (COVID-19) pandemic has led to more than 434 million confirmed cases and more than 5 million deaths. In addition, based on knowledge of previous vaccines and disease manifestations of SARS-CoV-2 infection, it also suggests that narcolepsy must be included as potential adverse events of particular interest to consider in pharmacovigilance studies.
On the recognized basis of inflammatory regulation of hypothalamic neurons in sickness behavior, we hypothesized that IL-1β, INF-γ and TNF-α pro-inflammatory cytokines inhibit orexinergic neurons promoting sleepiness after peripheral activation of the innate immune system induced by the novel COVID-19 vaccines. Because sleep and immunity are bidirectionally linked, sleepiness or sleep disturbance side effects reported after some of the COVID-19 vaccines advise an academic research line in the context of physiological or pathological neuroimmune interactions.
SLEEPLESS NIGHT AFTER COVID VACCINE GENERATOR
While studies on COVID-19 vaccines are ongoing, the knowledge about the reactogenic symptoms that can occur after vaccination and its generator mechanisms can be critical for healthcare professionals to improve compliance with the future vaccination campaign.
Coronavirus disease 2019 (COVID-19) represents a global healthcare crisis that has led to morbidity and mortality on an unprecedented scale.
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